Endocrine Abstracts

ObjectivesTo assess diagnostic and prognostic markers of permanent and transient postoperative diabetes insipidus.Patients and methodsThe study included 152 patients undergone endoscopic endonasal transsphenoidal surgery aged from 18 to 65 years with median 40 [31; 52] years. Seventy three patients had Cushing disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inactive adenoma, 1 –...

Introduction: The occurrence of autoimmune adverse events is a frequent complication of oncoimmunotherapy with antibody drugs to PD-1.Clinical Case: At the age of 33, the patient was diagnosed with melanoma, which was surgically removed. After 3 years, there was a progression with the appearance of liver metastases which were embolized with further initiation of oncoimmunotherapy with nivolumab. As a complication of this treatment the patient developed a...

Introduction: Corticotropinomas constitute up to 45% of aggressive pituitary tumors, which characterized by rapid and invasive growth, a high Ki-67 index, resistance to conventional treatments and recurrence in 15-20% of the cases. Progression of corticotroph tumor after bilateral adrenalectomy or Nelson’s syndrome is a frequent severe complication and may present with aggressive tumor behavior.Clinical case: A Cushing disease was diagnosed in a wom...

Background: Acromegaly is a chronic endocrine disease characterized by excessive secretion of somatotropic hormone (GH), which in turn leads to increased secretion of insulin-like growth factor 1 (IGF-1) in the liver. Many cells in the body are targets for these hormones. Excess of GH, in the vast majority of cases caused by hormone-producing pituitary adenoma, and IGF-1 leads to cellular and tissue growth of practically all organs and systems, including the bone and joint app...

Background: The combination of various endocrine tumours is presented both as hereditary syndromes and sporadic forms. Medullary thyroid cancer and prolactinoma are neuroendocrine tumours, the presence of these two pathologies simultaneously has not been previously described in the literature.Objective: To present a clinical case of a patient with giant prolactinoma and medullary thyroid cancer.Materials and Methods: To describe th...

Background: One of the complications of hypothyroidism is the disorder of the neuromuscular system. Myopathic changes often accompany hypothyroidism and are observed in 30-80% of patients. A distinctive feature of hypothyroid myopathies is the reversibility of clinical manifestations and significant improvement of well-being after levothyroxine compensation of the disease. However, the absence of a vivid clinical picture of hypothyroidism, combined with its rare occurrence, co...

Introduction: According to statistical data, the combination of chronic adrenal insufficiency and diabetes mellitus is the rarest among patients with autoimmune polyglandular syndrome type 2 (APS-2).Clinical Case: In 2017, a 32-year-old patient B. with excess body weight manifested type 2 diabetes mellitus with typical clinical symptoms of carbohydrate metabolism disorder. Metformin and gliclazide were recommended. After a viral pneumonia episode with ho...

Objectives: To assess the frequencies of hyponatremia and central diabetes insipidus (CDI) after transnasal adenomectomy and to identify its risk factors.Patients and methods: The study included 152 patients aged 18 to 65 years (median [Q1; Q3] 40 [31; 52]) who underwent endoscopic endonasal transsphenoidal surgery due to Cushing’s disease, acromegaly, prolactinoma, non-functioning pituitary adenoma, thyreotropinoma or Nelson’s syndrome at Endo...

Introduction: Water-electrolyte disorders are serious complications after transnasal adenomectomy for formations of the hypothalamic-pituitary region. The purpose of this work was to evaluate the incidence of postoperative hyponatremia in the tactics of active control of sodium levels in the blood.Materials and methods: The study included the results of a dynamic study of blood sodium levels in 53 patients (mean age 46.6 years [min 19; max 68]) with pitu...

Background: Pituitary disease registries are major instruments of epidemiological and clinical data collection used worldwide.Objective: To assess the epidemiological and clinical characteristics of acromegaly in Russia according to Russian hypothalamic and pituitary tumor registryMaterial and methods: Database of the Russian hypothalamic and pituitary tumor registry, which includes data from 84 regions of the country, was used for...